MIMA-123 evaluation Essay Example | Topics and Well Written Essays - 5000 words

MIMA-123 evaluation - Essay compositors caseDombrock defined an unrecognized red cell antigen, which was ultimately named Doa (Swanson et al.1965). Eight years later, the antithetical antigen to Doa was identified and appropriately named Dob (Molthan et al 1973). The devil antigens were put in the Dombrock blood group transcription (DO) and assigned IBST 014 by the multinational Society for Blood Transfusion (Lewis et al.1985).The Dombrock blood group started as a polymorphic system comprised of the two alleles, DOA and DOB. The antigens Doa and Dob are found on a glycosylphosphatidylinositol (GPI)-linked glycoprotein belonging to the ADP-ribosyltransferases (ARTs) family. ARTs catalyze the transfer of ADP-ribose from -NAD+ to certain aminic acid residues of target proteins (Ueda & Hayaishi, 1985). ADP-ribosylation is physiologically important because the process leads to protein inactivation, and in some cases pathogenecity because this action has been related to that of bacte rial toxins (Corda & Di Girolamo, 2003). In 1992, it was discovered that the Gregory (Gya) negative phenotype RBCs were also Do (a-b-) in addition to being Holley (Hy) and Joseph (Joa) negative as previously describe (Banks et al.1992). Gya and Hy are high prevalence antigens which were first described in 1967, while the Joa antigen was described in 1972 (Reid 2003). Through immunoblotting analysis, Gya, Hy, and Joa antigens were found on the same glycoprotein where the Do antigens reside (Spring et al.1994). The Gy (a-) phenotype was determined to be the cryptograph Dombrock (Donull) phenotype (Reid, 2003). Consequently, Gya, Hy, and Joa antigens were included in the Dombrock blood group system. In 2009, a new Do-related high-prevalence antigen named DOYA was discovered and added to the Dombrock group (Warke et al.2008 Daniels et al.2009), take the total to six distinct antigens in the Dombrock blood group. The current ISBT terminology for the Dombrock blood group system is shown in